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日常饮食调节小肠微生物组

作者:澳门葡京 时间:2020-09-06 10:03

本期文章:《细胞》:Online/在线发表

以色列魏茨曼科学研究所Eran Elinav和Hagit Shapiro研究组的最新研究表明,日常饮食调节小肠(SI)微生物组-上皮-免疫稳态和肠炎。相关论文于2020年9月3日在线发表在《细胞》杂志上。

在本文中,研究人员发现饮食含量和节律通过调控SI微生物组来调节SI上皮细胞(SIEC)昼夜变化的转录情况。研究人员利用SIEC II类主要组织相容性复合体(MHC)说明了这一概念,该复合体由不同的粘膜粘附SI共生菌昼夜调控,同时维持下游上皮内IL-10+淋巴细胞调控的SI屏障功能的昼夜节律。通过昼夜节律紊乱、进食时间或含量改变或上皮特异性MHC II类耗竭,改变这种昼夜调控的饮食微生物组II类MHC-IL-10-上皮屏障通路会导致大量微生物产物进入小肠,从而导致克罗恩病样肠炎。

总体而言,该研究重点介绍了可调SI微生物组、免疫和屏障功能的营养特征,并确定了该通路的饮食、上皮和免疫检查点,未来可在克罗恩病治疗过程中加以利用。

研究人员介绍,在24小时内,小肠暴露于昼夜变化的食物和微生物组产生的抗原压力,但保持精确的免疫稳态,当遗传易感性个体免疫稳态受到干扰时可能会导致克罗恩病。

附:英文原文

Title: Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis

Author: Timur Tuganbaev, Uria Mor, Stavros Bashiardes, Timur Liwinski, Samuel Philip Nobs, Avner Leshem, Mally Dori-Bachash, Christoph A. Thaiss, Elisha Y. Pinker, Karina Ratiner, Lorenz Adlung, Sara Federici, Christian Kleimeyer, Claudia Moresi, Takahiro Yamada, Yotam Cohen, Xiao Zhang, Hassan Massalha, Efi Massasa, Yael Kuperman, Pandelakis A. Koni, Alon Harmelin, Nan Gao, Shalev Itzkovitz, Kenya Honda, Hagit Shapiro, Eran Elinav

Issue&Volume: 2020-09-03

Abstract: Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varyingfood- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis,which when perturbed in genetically susceptible individuals, may lead to Crohn disease.Herein, we demonstrate that dietary content and rhythmicity regulate the diurnallyshifting SI epithelial cell (SIEC) transcriptional landscape through modulation ofthe SI microbiome. We exemplify this concept with SIEC major histocompatibility complex(MHC) class II, which is diurnally modulated by distinct mucosal-adherent SI commensals,while supporting downstream diurnal activity of intra-epithelial IL-10+ lymphocytes regulating the SI barrier function. Disruption of this diurnally regulateddiet-microbiome-MHC class II-IL-10-epithelial barrier axis by circadian clock disarrangement,alterations in feeding time or content, or epithelial-specific MHC class II depletionleads to an extensive microbial product influx, driving Crohn-like enteritis. Collectively,we highlight nutritional features that modulate SI microbiome, immunity, and barrierfunction and identify dietary, epithelial, and immune checkpoints along this axisto be potentially exploitable in future Crohn disease interventions.

DOI: 10.1016/j.cell.2020.08.027

Source: https://www.cell.com/cell/fulltext/S0092-8674(20)31069-2

期刊信息

Cell:《细胞》,创刊于1974年。隶属于细胞出版社,最新IF:36.216

官方网址:https://www.cell.com/

投稿链接:https://www.editorialmanager.com/cell/default.aspx

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